Prader-Willi Syndrome (PWS) is a lifelong genetic disorder that is usually present from birth. The syndrome is caused by a genetic abnormality in a region of the brain called the hypothalamus. The hypothalamus controls appetite and body temperature, and people with PWS have these functions affected. Symptoms of PWS include overeating, slow metabolism, low muscle tone, poor growth, behavioral disorders and intellectual disability. However, symptoms can vary from person to person and symptoms may increase with age. The cause of PWS is a deficiency or deletion of several genes on the hypothalamus, which is usually located in the brain. This deficiency causes a dysregulation in the level of the hormone leptin, which controls a person's appetite. This hormone tells the brain how much fat is in your body, which in turn controls appetite. In people with PWS, leptin levels are lower than normal, which causes a constant feeling of hunger and can lead to overeating behavior. Overeating in people with PWS can lead to life-threatening obesity. Obesity can lead to heart disease, diabetes and other serious health problems. It is therefore important that people with PWS keep their diet under strict control and exercise. The condition can also be managed with treatments such as behavioral therapy. There is no cure for PWS, but many treatments are available to manage symptoms. Most people with PWS need specialized care throughout their lives. Treatment options include behavioral therapy, diet and exercise management, hormone therapy, growth hormone therapy and surgery. Prader-Willi Syndrome is a lifelong genetic disorder. This leads to problems, especially with appetite control and metabolism. People with PWS require specialized care and a range of treatment options are available to manage symptoms.